Abstract
Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.
Original language | English |
---|---|
Pages (from-to) | 124-129 |
Number of pages | 6 |
Journal | Malaysian Journal of Medicine and Health Sciences |
Volume | 20 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2024 |
Keywords
- Animal model
- BDNF
- Exercise
- Stroke
- Wet cupping therapy
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Subadi, I., Sulastri, N., Machin, A., Hidayati, H. B., Ramadhan, N. A., Rahaju, A. S., Ardianto, C., & Sumartha, I. N. B. (2024). Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. Malaysian Journal of Medicine and Health Sciences, 20(4), 124-129. https://doi.org/10.47836/mjmhs20.4.16
Subadi, Imam ; Sulastri, Nur ; Machin, Abdulloh et al. / Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. In: Malaysian Journal of Medicine and Health Sciences. 2024 ; Vol. 20, No. 4. pp. 124-129.
@article{5585b30305d541fd8c1d2cc8d4d0df07,
title = "Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model",
abstract = "Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.",
keywords = "Animal model, BDNF, Exercise, Stroke, Wet cupping therapy",
author = "Imam Subadi and Nur Sulastri and Abdulloh Machin and Hidayati, {Hanik Badriyah} and Ramadhan, {Nanda Aulya} and Rahaju, {Anny Setijo} and Chrismawan Ardianto and Sumartha, {I. Nengah Budi}",
note = "Publisher Copyright: {\textcopyright} 2024 Universiti Putra Malaysia Press. All rights reserved.",
year = "2024",
month = jul,
doi = "10.47836/mjmhs20.4.16",
language = "English",
volume = "20",
pages = "124--129",
journal = "Malaysian Journal of Medicine and Health Sciences",
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publisher = "Faculty of Medicine and Health Sciences, University Putra Malaysia",
number = "4",
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Subadi, I, Sulastri, N, Machin, A, Hidayati, HB, Ramadhan, NA, Rahaju, AS, Ardianto, C & Sumartha, INB 2024, 'Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model', Malaysian Journal of Medicine and Health Sciences, vol. 20, no. 4, pp. 124-129. https://doi.org/10.47836/mjmhs20.4.16
Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. / Subadi, Imam; Sulastri, Nur; Machin, Abdulloh et al.
In: Malaysian Journal of Medicine and Health Sciences, Vol. 20, No. 4, 07.2024, p. 124-129.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model
AU - Subadi, Imam
AU - Sulastri, Nur
AU - Machin, Abdulloh
AU - Hidayati, Hanik Badriyah
AU - Ramadhan, Nanda Aulya
AU - Rahaju, Anny Setijo
AU - Ardianto, Chrismawan
AU - Sumartha, I. Nengah Budi
N1 - Publisher Copyright:© 2024 Universiti Putra Malaysia Press. All rights reserved.
PY - 2024/7
Y1 - 2024/7
N2 - Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.
AB - Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.
KW - Animal model
KW - BDNF
KW - Exercise
KW - Stroke
KW - Wet cupping therapy
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U2 - 10.47836/mjmhs20.4.16
DO - 10.47836/mjmhs20.4.16
M3 - Article
AN - SCOPUS:85206177544
SN - 1675-8544
VL - 20
SP - 124
EP - 129
JO - Malaysian Journal of Medicine and Health Sciences
JF - Malaysian Journal of Medicine and Health Sciences
IS - 4
ER -
Subadi I, Sulastri N, Machin A, Hidayati HB, Ramadhan NA, Rahaju AS et al. Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. Malaysian Journal of Medicine and Health Sciences. 2024 Jul;20(4):124-129. doi: 10.47836/mjmhs20.4.16