Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model (2024)

Abstract

Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalMalaysian Journal of Medicine and Health Sciences
Volume20
Issue number4
DOIs
Publication statusPublished - Jul 2024

Keywords

  • Animal model
  • BDNF
  • Exercise
  • Stroke
  • Wet cupping therapy

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Subadi, I., Sulastri, N., Machin, A., Hidayati, H. B., Ramadhan, N. A., Rahaju, A. S., Ardianto, C., & Sumartha, I. N. B. (2024). Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. Malaysian Journal of Medicine and Health Sciences, 20(4), 124-129. https://doi.org/10.47836/mjmhs20.4.16

Subadi, Imam ; Sulastri, Nur ; Machin, Abdulloh et al. / Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. In: Malaysian Journal of Medicine and Health Sciences. 2024 ; Vol. 20, No. 4. pp. 124-129.

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title = "Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model",

abstract = "Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.",

keywords = "Animal model, BDNF, Exercise, Stroke, Wet cupping therapy",

author = "Imam Subadi and Nur Sulastri and Abdulloh Machin and Hidayati, {Hanik Badriyah} and Ramadhan, {Nanda Aulya} and Rahaju, {Anny Setijo} and Chrismawan Ardianto and Sumartha, {I. Nengah Budi}",

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Subadi, I, Sulastri, N, Machin, A, Hidayati, HB, Ramadhan, NA, Rahaju, AS, Ardianto, C & Sumartha, INB 2024, 'Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model', Malaysian Journal of Medicine and Health Sciences, vol. 20, no. 4, pp. 124-129. https://doi.org/10.47836/mjmhs20.4.16

Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. / Subadi, Imam; Sulastri, Nur; Machin, Abdulloh et al.
In: Malaysian Journal of Medicine and Health Sciences, Vol. 20, No. 4, 07.2024, p. 124-129.

Research output: Contribution to journalArticlepeer-review

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T1 - Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model

AU - Subadi, Imam

AU - Sulastri, Nur

AU - Machin, Abdulloh

AU - Hidayati, Hanik Badriyah

AU - Ramadhan, Nanda Aulya

AU - Rahaju, Anny Setijo

AU - Ardianto, Chrismawan

AU - Sumartha, I. Nengah Budi

N1 - Publisher Copyright:© 2024 Universiti Putra Malaysia Press. All rights reserved.

PY - 2024/7

Y1 - 2024/7

N2 - Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.

AB - Introduction: Cupping therapy has been widely utilized as a complementary therapy, including in the treatment of stroke. This study aims to compare the effects of wet cupping therapy and exercise on brain-derived neurotrophic factor (BDNF) expression in animal models of stroke. Materials and methods: This study employed a post-test-only control group design. Twenty-four 3-month-old male Wistar rats were divided into four groups: sham group (n=6), stroke group (n=6), stroke+cupping group (n=6), and stroke+exercise group (n=6). Stroke animal models were induced by unilateral common carotid artery occlusion (UCCAO). Wet cupping therapy was administered twice a week for three weeks to the stroke+cupping group. In contrast, the stroke+exercise group participated in swimming activities scheduled for 20 minutes per day, three times a week over the same three-week period. Results: The mean of nerve cells expressing BDNF in the sham group was 41.33±22.17; the stroke group was 17.66±11.03; the stroke+cupping group was 24.50±26.82; and the stroke+exercise group was 60.16±30.94. Analysis of multiple comparisons among groups proved that there were no significant differences in BDNF expression between the stroke and sham group (p=0.102) and between the stroke+cupping and stroke group (p=0.626). Meanwhile, the BDNF expression in the stroke+exercise group was significantly higher than in the stroke group (p=0.06). Apart from that, the BDNF expression in the stroke+exercise group was significantly higher than stroke+ cupping group (p=0.018). Conclusion: In the stroke animal model, exercise demonstrated greater efficacy in upregulating the expression of BDNF compared to wet cupping therapy.

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KW - BDNF

KW - Exercise

KW - Stroke

KW - Wet cupping therapy

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JO - Malaysian Journal of Medicine and Health Sciences

JF - Malaysian Journal of Medicine and Health Sciences

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Subadi I, Sulastri N, Machin A, Hidayati HB, Ramadhan NA, Rahaju AS et al. Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model. Malaysian Journal of Medicine and Health Sciences. 2024 Jul;20(4):124-129. doi: 10.47836/mjmhs20.4.16

Comparison of the Effects of Wet Cupping Therapy and Exercise on Brain-derived Neurotrophic Factor Expression in Stroke-animal Model (2024)
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